Run the show Crossword Clue

 The answer to the crossword clue "Run the show" can be DIRECT or EMCEE.

DIRECT means to be in charge of something and to make all the decisions.

EMCEE means to introduce performers and keep the show moving smoothly.

The specific answer that you are looking for may depend on the context of the crossword puzzle. For example, if the clue is specifically looking for someone who is in charge of a production, then the answer would be DIRECT. However, if the clue is more general and is simply looking for someone who is in charge of an event, then the answer could be either DIRECT or EMCEE.

I hope this helps!