Lose one’s shirt, say Crossword Clue

 The crossword clue "lose one's shirt, say" can be answered with the word GAMBLE. It is a 6-letter word that can be used as a crossword clue.

Gamble means to risk money or something else of value on an uncertain outcome. It can be used in a literal sense, such as when someone gambles on the outcome of a sporting event. It can also be used in a figurative sense, such as when someone gambles on a new business venture.

In the context of the crossword clue, "lose one's shirt, say", the answer is gamble because it is a word that is associated with losing money. It is also a relatively short word, making it a good fit for a crossword clue.

Here are some other possible answers for the crossword clue "lose one's shirt, say":

BET (4 letters)

RISK (5 letters)

WAGER (6 letters)

SPECULATE (10 letters)

VENTURE (7 letters)