Injure, as a knee Crossword Clue

 The answer to the crossword clue "Injure, as a knee" is sprain.

A sprain is an injury to a ligament, which is a band of tissue that connects bones together. Sprains can occur in any joint, but they are most common in the knees. Symptoms of a sprained knee include pain, swelling, and bruising.

Here are some other possible answers to the clue:

strain

twist

hurt

injure

damage

afflict

The specific answer that is correct will depend on the context of the crossword puzzle.