“___, I guess. At least the week’s over.” Crossword Clue

 The answer to the crossword clue "“___, I guess. At least the week’s over.”" is TGIF. This is a 4-letter acronym that stands for "Thank God It's Friday."

The clue is suggesting that the person is tired of the week and is looking forward to the weekend. It can also be used to express relief or satisfaction that the week is over.

The acronym "TGIF" is often used in a humorous or ironic way, but it can also be used sincerely to express gratitude for the end of the week.

I hope this helps!