___ de’ Medici, who founded the Medici dynasty Crossword Clue

 The answer to the crossword clue "___ de’ Medici, who founded the Medici dynasty" is Cosimo. Cosimo de' Medici was the founder of the Medici dynasty, which ruled Florence and later Tuscany for centuries. He was a wealthy banker and politician who used his wealth and influence to promote the arts and learning in Florence. He is considered one of the most important figures of the Italian Renaissance.

The clue is a cryptic clue, so it is not a literal definition of the answer. The wordplay in the clue is that the word "de" can be interpreted as both "of" and "the." So, "Cosimo de’ Medici" can be interpreted as "Cosimo, of the Medici."

I hope this helps!